Probiotics are live microbial food suppliments or components of bacteria which have been shown to have beneficial effects on human health. They are perceived to exert such effects by changing the composition of gut microbiota.sveral probiotic preparations seem to have promised in prevention and treatment of various diseases. Our aim was to demonstrate the hepatoprotective and antioxidant effects of probiotics which include Bacillus coagulans and Saccharomyces cerevisae ccl4 incuded hepatotoxic animals with a view to explore its use for the treatment of hepatotoxicity in humans. Antioxidant activity of the probiotics was evaluated by Reducing power and H2O2 scavenging methods. There was a significant decrease in, AST, ALT in treatment group as compared to the hepatotoxic group. In the histopathological study the hepatotoxic group showed hepatocytic necrosis and inflammation. The treatment group showed minimal inflammation and their lobular architecture was normal. It should be concluded that the Probiotics were not able to revert completely hepatic injury induced by ccl4, but it could limit the effect of these drugs in liver. The effect of probiotics was compared with standard drug silymarin. Thus the present study revealed that the probiotics have significant radical scavenging and hepatoprotective activity
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